Cisplatin-Based Chemotherapy Followed by Maintenance Avelumab in UTUC

Recruiting now · Phase 2

Conditions studied: Upper Tract Urothelial Carcinoma

In brief

A Prospective Phase II Study of Adjuvant Cisplatin-Based Chemotherapy followed by Maintenance Avelumab in Upper Tract Urothelial Carcinoma

Key facts

Study ID: NCT07225374
Run by: Samsung Medical Center
People needed: 48
Starts: 2025-09-16
Expected to finish: 2029-07-02
Last updated by the study team: 2025-11-06

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Must be aged 19 years or more
Must have histologically or cytologically proven UTUC arising from renal pelvis and/or ureter.
Must have histological evidence of high-risk muscle-invasive disease (i.e., pT2\~ T4) and/or N+ disease.
Must have an ECOG performance status of 0 to 1
Received at least 3 or 4 cycles of adjuvant cisplatin-based chemotherapy, and proved to have no evidence of disease recurrence with imaging studies, urine cytology and cystoscopy
At least 3 weeks since the last surgical procedures or chemotherapy prior to enrolment. Subjects must have recovered to <Grade 2 from all acute toxicities or toxicity must be deemed irreversible by the investigator.
Adequate marrow function without growth factor support or transfusion dependency A. Neutrophil 1,500 cells/μL or more B. Platelet count 100,000/μL or more C. Hemoglobin 9.0 g/dL or more
Adequate renal function with serum creatinine 1.5 x ULN or a calculated creatinine clearance ≥ 50 mL/min using the CockcroftGault or MDRD formulas
Adequate hepatic function A. Bilirubin 1.5 times upper limit of normal (x ULN) or less; does not apply to subjects with Gilbert's syndrome diagnosed as per institutional guidelines. B. AST (SGOT) and ALT (SGPT) 3 x ULN or less; if liver metastases are present, then 5 x ULN is allowed.
Women of childbearing potential must use effective contraception continuously for at least 30 days after the final dose of avelumab. At least one method classified as "highly effective" (failure rate < 1%) must be employed (see Table 1).
Written and voluntary informed consent understood, signed and dated.
Negative serum or urine pregnancy test at screening for women of childbearing potential.

You may not qualify if…

Ongoing treatment with an anticancer agent not contemplated in this protocol
Radiologic finding consistent with metastatic disease
Severe medical or psychological illness that preclude participation to study, including any history of clinically relevant coronary artery disease or myocardial infarction within the last 3 years, New York Heart Association (NYHA) grade III or greater congestive heart failure, cerebrovascular attack within the prior year, or current serious cardiac arrhythmia requiring medication except atrial fibrillation
Non-tolerable > Grade 2 neuropathy or evidence of unstable neurological symptoms within 4 weeks of Cycle 1 Day 1
Major surgery, other than diagnostic surgery or transurethral resection, within 4 weeks prior to Cycle 1 Day 1, without complete recovery
Double primary cancer of other site(s) or a history of other malignancies, except for cured ones at the discretion of investigator
Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy.
Subjects who have exhibited allergic reactions to study treatment.
Concomitant disease or condition that could interfere with the conduct of the study, or that would, in the opinion of the Investigator, pose an unacceptable risk to the subject in this study.
Subject with legal incapacity or limited legal capacity. Dementia or significantly altered mental status that would limit the understanding or rendering of informed consent and compliance with the requirements of this protocol. Unwillingness or inability to comply with the study protocol for any reason.
Current use of immunosuppressive medication, EXCEPT for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b. Systemic corticosteroids at physiologic doses ≤ 10 mg/day of prednisone or equivalent; c. Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication). 12) Active autoimmune disease requiring systemic immunosuppressive treatment. Patients with controlled autoimmune disease not requiring systemic immunosuppressive treatment including diabetes type I, vitiligo, psoriasis, or hypo- or hyperthyroid diseases not requiring immunosuppressive treatment are eligible.
Prior organ transplantation including allogenic stem-cell transplantation.
Vaccination within 4 weeks of the first dose of avelumab and while on trials is prohibited except for administration of inactivated vaccines.
Persisting toxicity related to prior therapy (NCI CTCAE Grade >
; however, alopecia, sensory neuropathy Grade ≤ 2, or other Grade ≤ 2 not constituting a safety risk based on investigator's judgment are acceptable.
Lactating Women Must discontinue breastfeeding during study treatment and for at least 30 days after administration of the final dose of study drug.

Where it is running

Samsung Medical Center — Seoul, Gangnam, South Korea (enrolling)

Full record on ClinicalTrials.gov

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