The Effects of Ketone Supplements With Carbohydrates on Cycling Performance Above Lactate Threshold
Starting soon · Early Phase 1
Conditions studied: Exogenous Ketosis
In brief
The goal of this clinical trial is to determine whether a ketone supplement with carbohydrates extends time to fatigue during cycling compared with a carbohydrate-only supplement in healthy, trained cyclists aged 18-55. The main questions it aims to answer are: Is the time to fatigue increased with ketone supplementation and carbohydrates compared to carbohydrates alone? Will ketone supplementation with carbohydrates produce lower blood lactate concentrations compared to carbohydrates alone? Participants will: * Perform a staged maximal cycling exercise test on a stationary bicycle. * Finger prick to obtain a drop of blood for lactate measurements. * Wear a mask connected to a metabolic cart to measure breath contents. * Perform a cycling exercise test to fatigue for at least one hour. * Consume either a ketone supplement with carbohydrates or a carbohydrate supplement during the exercise at least 4 times. * Finger prick to obtain a drop of blood to measure blood lactate, ketones, and glucose.
Key facts
- Study ID
- NCT07224282
- Run by
- University of Oklahoma
- People needed
- 15
- Starts
- 2025-11-17
- Expected to finish
- 2026-05-03
- Last updated by the study team
- 2025-11-04
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Highly trained males and females
- Ages 18-55
- Greater than or equal to six hours of cycling training per week
- Participants from the University of Oklahoma, Oklahoma cycling teams, and local cycling races in Oklahoma.
You may not qualify if…
- Cardiovascular disease
- Respiratory disease
- Gastrointestinal disease
- Metabolic disease
- Kidney disease
- Neurological disease
- Pregnancy
Where it is running
- University of Oklahoma — Norman, Oklahoma, United States
Full record on ClinicalTrials.gov
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