Hippocampal Oscillations During Exploration

Recruiting now · Not applicable

Conditions studied: Epilepsy

In brief

The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.

Key facts

Study ID

NCT07224191

Run by

NYU Langone Health

People needed

56

Starts

2026-02-25

Expected to finish

2028-10-08

Last updated by the study team

2026-07-08

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All subjects:
• Adults (18-70 years)
• Able to provide informed consent
• Aim 1: Surgical epilepsy patients' inclusion criteria
• Implanted hippocampal depth electrodes for Stage 1 epilepsy surgery
• MMSE>=24
• Aim 2: RNS patients Inclusion criteria
• Implanted RNS device with at least one hippocampal depth electrode
• At least 5 months post-implantation to avoid the post-implant effect
• Have a relatively low number of seizures, defined as <1 generalized tonic-clonic or other seizure with potential to fall or cause injury per month
• Able to walk and wear research equipment without assistance
• MMSE>=24
• Aim 2: Healthy Control Inclusion criteria • Able to walk and wear research equipment without assistance

You may not qualify if…

• RNS patients, Aim 2:
• Any generalized tonic-clonic seizure within the last week
• All subjects:
• Legally blind
• Smoking tobacco, marijuana, recreational drugs or alcohol use within 1 week of cognitive testing
• Unable to give informed consent
• Pregnancy

Where it is running

• NYU Langone Health — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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