Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias

Running, not enrolling

Conditions studied: Alzheimer Disease, Dementia, Cognitive Dysfunction

In brief

Blood-based ADRD biomarkers show tremendous promise as a non-invasive method to predict and diagnose ADRD. We will measure changes in these biomarkers to determine whether their ability to predict ADRD differs by sex or by other characteristics, and develop a sex-specific ADRD risk score for personalized medicine and clinical trials.

Key facts

Study ID

NCT07224139

Run by

Anne Murray

People needed

13435

Starts

2022-07-01

Expected to finish

2027-08-01

Last updated by the study team

2025-11-04

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• We will use de-identified data and biospecimens originally collected for a large binational NIA-funded ASPirin in Reducing Events in the Elderly (ASPREE) randomized clinical trial and ongoing observational follow-up (U19 AG062682) for analysis.

You may not qualify if…

• None

Where it is running

• Foundation for Atlanta Veterans Education and Research, Inc. — Decatur, Georgia, United States
• Hennepin Healthcare Research Institute — Minneapolis, Minnesota, United States
• Regents of the University of Minnesota - Advanced Research & Diagnostic — Minneapolis, Minnesota, United States
• Wake Forest University — Winston-Salem, North Carolina, United States
• Monash University — Melbourne, Victoria, Australia

Full record on ClinicalTrials.gov

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