Helicobacter Pylori Screening and Treatment in the At-risk South Florida Community- AIM 1

Running, not enrolling · Phase 4

Conditions studied: H Pylori Infection, H Pylori Gastritis, Gastric Cancer

In brief

H. pylori is an infection of the stomach that can cause chronic gastritis, gastric cancer and peptic ulcer disease. The goal of this study is to screen people for this infection and offer treatment for those who test positive for the infection. By treating those who are positive for H. pylori, there is an opportunity to prevent gastritis, peptic ulcer disease, and even gastric cancer.

Key facts

Study ID

NCT07224035

Run by

University of Miami

People needed

500

Starts

2022-10-15

Expected to finish

2027-11-06

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults ≥ 18 years of age

You may not qualify if…

• Adults with a personal history of gastric cancer
• Adults with prior history of H. Pylori (HP) treatment and confirmed eradication
• Adults unable to consent
• Adults unable to consent in their preferred language
• Pregnant women, those who are breastfeeding, or those who are planning to become pregnant/breastfeed
• Prisoners
• Persons who are allergic, hypersensitive, or unable to take any of the components of the medication regimen VOQUEZNA® Triple Pak®:
• vonoprazan
• amoxicillin or any other beta-lactams (e.g. penicillins and cephalosporins)
• clarithromycin or any other macrolide antimicrobial (e.g. erythromycin)
• Persons presently taking any of the following:
• Rilpivirine-containing products
• Pimozide
• Lomitapide, lovastatin, simvastatin, atorvastatin, and pravastatin
• Ergot alkaloids
• Colchicine (if with kidney or liver impairment)
• Lurasidone
• Drugs known to prolong the QT interval (e.g., pimozide).
• Class IA (e.g., quinidine, procainamide, disopyramide) or Class III (e.g., dofetilide, amiodarone, sotalol) antiarrhythmic agents
• Verapamil, amlodipine, diltiazem, nifedipine
• Nateglinide, pioglitazone, repaglinide, rosiglitazone, and insulin
• Quetiapine
• Warfarin
• Benzodiazepines (e.g. triazolam, midazolam)
• Persons who have any of the following, as they may be prone to adverse effects from the medication regimen:

Where it is running

• University of Miami — Miami, Florida, United States

Full record on ClinicalTrials.gov

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