Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial

Enrolling by invitation · Not applicable

Conditions studied: Acute Respiratory Failure

In brief

The Hyperangulated versus Standard Geometry Laryngoscope Blade (ANGLE) Trial is a multi-center, non-blinded, parallel-group, randomized clinical trial evaluating the effect of use of a hyperangulated video laryngoscope blade versus use of a standard geometry video laryngoscope blade. Critically ill adults undergoing tracheal intubation in participating EDs and ICUs who meet eligibility criteria will be enrolled and randomly assigned in a 1:1 ratio to either intubation using a hyperangulated video laryngoscope blade or a standard geometry video laryngoscope blade. The primary outcome is the incidence of successful intubation on the first attempt. The secondary outcome is incidence of hypoxemia during the interval between induction and 2 minutes after tracheal intubation.

Key facts

Study ID

NCT07223762

Run by

Vanderbilt University Medical Center

People needed

2500

Starts

2025-12-30

Expected to finish

2027-05-01

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient is located in a participating unit.
• Planned procedure is orotracheal intubation using a laryngoscope.
• Planned operator is a clinician expected to routinely perform tracheal intubation in the participating unit.

You may not qualify if…

• Patient is known to be less than 18 years old.
• Patient is known to be pregnant.
• Patient is known to be a prisoner.
• Immediate need for tracheal intubation precludes safe performance of study procedures.
• Operator has determined that use of a direct laryngoscope is required for the optimal care of the patient.
• Operator has determined that use of a hyperangulated video laryngoscope blade or a standard geometry video laryngoscope blade is required or contraindicated for the optimal care of the patient either because of factors related to the patient (e.g., patient's upper airway anatomy requires a specific blade type) or the operator (e.g., treating clinicians lack sufficient comfort with one of the blade types).

Where it is running

• University of California, Los Angeles — Los Angeles, California, United States
• Stanford University — Stanford, California, United States
• University of Colorado, Denver Anschutz Medical Campus — Denver, Colorado, United States
• Denver Health Medical Center — Denver, Colorado, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Our Lady of the Lake Hospital, Inc. — Baton Rouge, Louisiana, United States
• Ochsner Clinic Foundation — Jefferson, Louisiana, United States
• Lsu/Umcno — New Orleans, Louisiana, United States
• University of Maryland Baltimore — Baltimore, Maryland, United States
• Lahey Clinic, Inc — Burlington, Massachusetts, United States
• Hennepin Healthcare component - Hennepin County Medical Center — Minneapolis, Minnesota, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States
• The Ohio State University — Columbus, Ohio, United States
• Oregon Health & Science University — Portland, Oregon, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• Baylor Scott & White Research Institute — Dallas, Texas, United States
• Sentara Norfolk General — Norfolk, Virginia, United States

Full record on ClinicalTrials.gov

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