Handgrip Training and Brain Blood Flow Regulation

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Inactivity/Low Levels of Exercise

In brief

This study aims to investigate the effect of isometric handgrip training on brain blood vessel function in physically inactive adults. Isometric handgrip training is a promising strategy for lowering blood pressure and improving vascular health, but no previous investigations have studied the effect of training on markers of brain blood vessel function. Based on previous work showing improvements in vascular function after isometric handgrip training, we hypothesize that isometric handgrip training will improve key markers of cerebrovascular function.

Key facts

Study ID

NCT07223645

Run by

Florida State University

People needed

40

Starts

2025-10-27

Expected to finish

2028-10-27

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 to 35 years old
• Body mass index ≤30 kg/m2 (without obesity)
• Physically inactive (not meeting the current recommendations of ≥150 minutes per week of moderate-to-vigorous aerobic exercise and not ≥2 days per week of resistance training) in last 6 months
• Have a smartphone and are willing to download mobile applications used in this project

You may not qualify if…

• Having an overt chronic condition (e.g., cardiovascular, cerebrovascular, etc.)
• Being pregnant, planning to become pregnant, or breastfeeding/lactating
• Regular use of nicotine products in the past 6 months
• Recent head injury/trauma or concussion

Where it is running

• Florida State University — Tallahassee, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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