PILOT Phase: BPD Study

Running, not enrolling · Not applicable

Conditions studied: Borderline Personality Disorder

In brief

This pilot study aims to identify the area of the brain best suited for the treatment of Borderline Personality disorder (BPD). The study investigators will test whether repetitiveTranscranial Magnetic Stimulation (rTMS), a gentle non-invasive brain stimulation method, can improve regulation of emotions and impulsivity in individuals with BPD. This study will enroll up to 20 participants. Participant will be consented for the study remotely via a secure internet platform called Zoom. Participants will undergo 1 Magnetic Resonance Imaging or MRI scan and up to 3 brain stimulation of transcranial magnetic stimulation or TMS sessions, and cognitive behavioral testing on a computer. Participants will complete 4 in-person visits over the course of up to 3 weeks.

Key facts

Study ID

NCT07223619

Run by

University of California, Los Angeles

People needed

20

Starts

2024-01-05

Expected to finish

2027-12-31

Last updated by the study team

2026-02-03

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age of 18-65
• DSM-5 Diagnosis of Borderline Personality Disorder (BPD) based upon a psychiatric evaluation and ZAN-BPD scale
• Fluent English speaker
• Ability to give informed consent

You may not qualify if…

• Medical conditions that prevent TMS or MRI to be performed safely upon evaluation by the study psychiatrist
• Active alcohol or drug abuse of such severity that it would pose a risk for TMS administration (i.e., unstable motor thresholds or increased risk for seizure)
• Active suicidal plan
• Current diagnosis of Psychotic or Bipolar disorders

Where it is running

• Semel Institute/ UCLA TMS — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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