Treatment Landscape and Real-World Dosing Patterns With CDK4/6 Inhibitors for Breast Cancer in Portugal

Completed

Conditions studied: Breast Cancer

In brief

Assess and characterize the real-world cyclin-dependent kinase 4/6 inhibitor (CDKI) use in advanced/metastatic breast cancer (a/mBC), evaluate treatment persistence, and quantify CDKI dose adjustments in Portugal. This study used secondary data from the IQVIA database that collects data from hospital drug consumption. The study included 16 public hospitals across Portugal, for which data on consumption of drugs used in hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2-) a/mBC treatment was available. Patient selection was based on a set of criteria considering all patients with treatments in the a/mBC setting with use of at least one CDKI from November 2018 to May 2023.

Key facts

Study ID

NCT07223476

Run by

Novartis Pharmaceuticals

People needed

1926

Starts

2024-03-29

Expected to finish

2024-07-01

Last updated by the study team

2025-10-31

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female patients of all ages.
• Patients with at least one CDKI consumption from November 2018 to May 2023.
• Patients with consumptions in Gynecology and Oncology specialties.

You may not qualify if…

• Consumption patterns of target drugs that are not compatible with any known a/mBC treatment regimen.
• Patients in early stages of breast cancer.

Where it is running

• Novartis — East Hanover, New Jersey, United States

Full record on ClinicalTrials.gov

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