Learning Amyloid and Tau Results

Enrolling by invitation

Conditions studied: Alzheimer Disease

In brief

This is a prospective, single-cohort, single-center, observational study to assess if learning one's Alzheimer's disease biomarker test result impacts longitudinal psychosocial, behavioral, and neuropsychological outcomes, and to identify factors that moderate and mediate these outcomes. Participants enrolled in this study are requested to complete surveys at four timepoints after learning their Alzheimer's biomarker test results.

Key facts

Study ID

NCT07222930

Run by

University of Wisconsin, Madison

People needed

240

Starts

2026-02-17

Expected to finish

2029-06-01

Last updated by the study team

2026-06-24

Who can join

Age: 45 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Willing to provide informed consent.
• Willing to comply with all study procedures and be available for the duration of the study.
• Individuals at least 45 years of age.
• Enrolled in Wisconsin Registry for Alzheimer's Prevention (WRAP) or Alzheimer's Disease Research Center Clinical Core (ADRC)
• Previously adjudicated as cognitively unimpaired having mild cognitive impairment (MCI), or impaired but do not meet diagnostic criteria for mild cognitive impairment or dementia (classified as "Impaired-Not MCI" by the WRAP and ADRC cohorts) at their last WRAP or ADRC study visit at the time of enrollment into this study
• Have completed or able to complete amyloid and/or tau PET scans as part of a UW Alzheimer's Research Study

You may not qualify if…

• Diagnosis of dementia at the time of enrollment as determined by the most recent parent WRAP/ADRC study visit diagnostic consensus conference using standard NIA-AA 2011 diagnostic criteria. Participants who develop dementia after enrolling into this study may remain enrolled if they maintain decisional capacity and are able to follow study instructions and procedures.
• Individuals who lack decisional capacity to provide informed consent as determined by significant difficulty in understanding materials and information about study procedures during recruitment and/or informed consent discussions.
• Not suitable for study participation due to other reasons at the discretion of the investigators.

Where it is running

• University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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