Effects of P-TIOX and Tixel Combined on Reducing Eye Wrinkles

Running, not enrolling · Not applicable

Conditions studied: Periocular Fine Wrinkles

In brief

This study looks at whether using a cosmeceutical called P-TIOX together with a treatment called Tixel can reduce fine lines and wrinkles around the eyes better than Tixel treatment alone. Tixel is an FDA-approved device that uses heat to improve skin texture and firmness. P-TIOX is a topical product with ingredients that may help improve the skin's appearance and elasticity. One side of the face will be treated with both P-TIOX and Tixel, while the other side will receive Tixel only. The study will last about 9 weeks and will include several treatments and evaluations using photos and expert assessments. Participants may notice improvement in the skin around their eyes. The results will help doctors understand if this combination treatment is more effective.

Key facts

Study ID: NCT07222176
Run by: Main Line Center for Laser Surgery
People needed: 20
Starts: 2025-06-01
Expected to finish: 2027-06-01
Last updated by the study team: 2025-10-29

Who can join

Age: 30 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Severity of 2, 3, or 4 based on the 5-point severity scale of both periocular areas
30 years of age or older
Willingness to comply with study visits
Willingness to discontinue use of other topical cosmeceuticals/retinoids to the periocular region for the duration of the study

You may not qualify if…

Pregnant or breastfeeding
Prior treatment with periocular laser, energy-based devices, neuromodulators, or dermal fillers within the past six months
Prior surgical intervention in the periocular region within the past twelve months
Use of topical retinoids in the periocular area within the past four weeks
Known hypersensitivity to any component of P-TIOX
Presence of active dermatologic or ocular disease in the treatment area
Active systemic infection
Active cold sore/herpes labialis infection

Where it is running

Main Line Center for Laser Surgery — Ardmore, Pennsylvania, United States

Full record on ClinicalTrials.gov

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