Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Post Operative Pain, Spinal Surgery

In brief

The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surgery and collect preliminary data to inform a larger clinical trial that will test the opioid-sparing effects of methadone at 3 months after spine surgery.

Key facts

Study ID

NCT07222072

Run by

The Cleveland Clinic

People needed

120

Starts

2025-11-15

Expected to finish

2028-10-01

Last updated by the study team

2025-12-17

Who can join

Age: 18 and older, up to 72. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult ≥ 18 years of age
• Scheduled for multilevel lumbar and/or thoracic spine fusion (primary or revision)

You may not qualify if…

• <18 or >72 Years of age
• Body Mass Index >40
• Known allergy to methadone
• Pregnant females
• Non-English-speaking patients

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.