Brain Autoregulation Research Study

Withdrawn before enrolling · Not applicable

Conditions studied: Hypotension During Surgery, Hypotension Postprocedural

In brief

Randomized, multi-site, study assessing the feasibility of lower limit of autoregulation targeted mean arterial pressure (MAP) vs. standard MAP management in neonates undergoing cardiac surgery with cardiopulmonary bypass. After eligibility screening and consent, subjects will be randomized to either the intervention (study) or control group.

Key facts

Study ID

NCT07221721

Run by

Jennie E Minnich

People needed

0

Starts

2026-06-01

Expected to finish

2028-12-01

Last updated by the study team

2026-07-15

Who can join

Age: 0 and older, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All neonates (<30 days of age)
• Undergoing cardiothoracic surgery with cardiopulmonary bypass

You may not qualify if…

• Less than full term (<37 weeks gestation)
• Weight < 2.50kg
• Genetic abnormality or syndrome except heterotaxy syndrome
• Major non-cardiac anomalies (e.g. congenital diaphragmatic hernia, - omphalocele, holoprosencephaly, anencephaly)

Where it is running

• The Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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