Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin
Withdrawn before enrolling · Phase 2/Phase 3
Conditions studied: Clostridioides Difficile, Vancomycin Resistance Enterococcus Faecium
In brief
The purpose of this study is to evaluate the ability of oral vancomycin in preventing Clostridioides difficile infection (CDI) in patients that are simultaneously receiving antibiotics. Participants in this study will be placed randomly into two groups. The oral vancomycin treatment group will receive oral vancomycin two times per day simultaneously with an antibiotic plus two additional days. The no oral vancomycin control group will receive the current standard of care, which is an antibiotic and no oral vancomycin. Participation in this study will last approximately 3 months.
Key facts
- Study ID
- NCT07221708
- Run by
- University of Maryland, Baltimore
- People needed
- 0
- Starts
- 2027-01-01
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-07-29
Who can join
Age: 65 and older, up to 100. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 65 years or older
- Receive systemic antibiotics in the last 90 days
- Hospitalized anywhere in the last 90 days
- History of C diff colonization without history of C diff colitis (infection)
- Provide informed consent
- Read and understand the English language
- Not current taking probiotics
- Lack of allergy or contraindications to receive vancomycin
- Ability to take oral medications
- Not receiving medications that can be used to treat or prevent C diff
You may not qualify if…
- Age 64 years or younger
- Has not received systemic antibiotics in the last 90 days
- Has not been hospitalized in the last 90 days
- History of C diff colonization with a history of C diff colitis (infection)
- Not provided informed consent
- Cannot read and understand the English language
- Currently receiving probiotics
- Allergy or contraindications to receive vancomycin
- Unable to take oral medications
- Receiving medications that can be used to treat or prevent C diff
Where it is running
- University of Maryland Baltimore Washington Medical Center — Glen Burnie, Maryland, United States
Full record on ClinicalTrials.gov
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