Venous Compression in Fontan
Recruiting now · Not applicable
Conditions studied: Single-ventricle, Fontan Circulation
In brief
The aim of this study is to investigate whether venous compression garments increase exercise stroke volume in patients with Fontan circulation. To address this aim, we will test the following hypotheses: 1. Acute and chronic external venous compression will increase exercise stroke volume in patients with Fontan circulation. 2. Patients with significant venous varicosities will have a greater response to venous compression. Participants will: * Undergo submaximal exercise testing in MRI to measure venous return and exercise stroke volume with and without the wearing of compression garments * Undergo submaximal exercise testing on a seated upright exercise ergometer with concurrent measurement of stroke volume with and without the wearing of compression garments * A subset of participants will repeat both testing visits after wearing compression garments for 2-weeks during waking hours. Participants will: * Undergo submaximal exercise testing in MRI to measure venous return and exercise stroke volume with and without the wearing of compression garments * Undergo submaximal exercise testing on a seated upright exercise ergometer with concurrent measurement of stroke volume with and without the wearing of compression garments * A subset of participants will repeat both testing visits after wearing compression garments for 2-weeks during waking hours.
Key facts
- Study ID
- NCT07220226
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 20
- Starts
- 2026-05-10
- Expected to finish
- 2027-11-01
- Last updated by the study team
- 2026-07-30
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients at UTSW aged 18-45 years old with a Fontan circulation.
You may not qualify if…
- NYHA Class 4
- Severe AV valve regurgitation
- Severe ventricular dysfunction
- Large ascites
- Significant varicosities
- Atrio-pulmonary (AP) Fontan
- Known Fontan thrombus
- Poorly controlled arrythmia
- Unplanned cardiac admission in the last 6 months
- Cyanosis (resting O2 saturation <85%)
- Pregnant
- Common femoral vein obstruction >50% to be performed following completion of informed consent.
- Healthy Controls:
- Healthy control participants will be recruited on the basis of having no known chronic diseases and not currently taking any cardiovascular medications.
Where it is running
- UT Southwestern Medical Center — Dallas, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.