Effect of Activated Charcoal on Serum Osmolality, Osmolal Gap, and Enzymatic Ethylene Glycol Assay

Running, not enrolling

Conditions studied: Osmolality Disturbance, Lab Interference

In brief

The goal of this observational study is to determine whether a clinically relevant dose of activated charcoal raises the serum osmolality and osmolal gap in a population of healthy volunteers. Secondarily to determine whether the same dose creates a false positive result using an enzymatic assay. 1. Does a clinically relevant dose of commercially available activated charcoal raise the osmolal gap above the baseline of a healthy volunteer? 2. Does the same dose of charcoal cause a false positive enzymatic assay for ethylene glycol? Participants will be asked to consume a dose of activated charcoal and have serial blood draws for laboratory measurements.

Key facts

Study ID

NCT07220031

Run by

State University of New York - Upstate Medical University

People needed

8

Starts

2025-11-15

Expected to finish

2026-07-31

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adults

You may not qualify if…

• Any medical comorbidities
• Recent illness
• Pregnancy
• Prisoners
• Non-English speaking
• Weight > 100 kg

Where it is running

• Upstate Medical University Clinical Research Unit — Syracuse, New York, United States

Full record on ClinicalTrials.gov

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