Boosting Exercise Adherence in Knee Osteoarthritis

Starting soon · Not applicable

Conditions studied: Osteoarthritis, Knee

In brief

This project, conducted within the Department of Veterans Affairs Healthcare System (VHA), will test the effectiveness of an intervention to improve adherence to home exercise among Veterans receiving physical therapy (PT) for knee osteoarthritis (OA). The intervention, "Boosting Exercise Adherence in Knee Osteoarthritis" (BOOST-OA), has two phases. During the initiation phase (first 3 months of PT care), patients will receive tools and activities to address outcome expectations, action self-efficacy, goal-setting and monitoring. During the behavior maintenance phase (starting after PT care and continuing for 9 months), patients will receive health coaching calls that address satisfaction with outcomes, relapse prevention planning and independent monitoring. There are three main study aims: (1) examine improvements in patient outcomes, such as physical function, following BOOST-OA; (2) explore patient characteristics that lead to difference in reported improvements; and (3) interview participants and clinicians about their experience with BOOST-OA to inform future implementation.

Key facts

Study ID

NCT07219732

Run by

VA Office of Research and Development

People needed

360

Starts

2026-09-14

Expected to finish

2030-12-31

Last updated by the study team

2026-07-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of knee OA (verified from the EHR)
• Knee pain for 3 months
• Knee pain on most days of the previous month,
• Average knee pain 3 (on a scale of 0-10),
• Self-report of some difficulty with walking or stair climbing.

You may not qualify if…

• Systemic rheumatic conditions, fibromyalgia, gout (knee)
• Dementia, psychosis or active substance abuse disorder
• Meniscus or knee ligament tear in the past 6 months
• Lower extremity surgery in past 6 months or planned in next 9 months
• Severe hearing or visual impairment
• Serious / terminal illness
• Hospitalization for a cardiovascular event, past 3 months
• Unstable angina
• History of ventricular tachycardia
• Unstable chronic obstructive pulmonary disease
• Uncontrolled hypertension (diastolic >110 mm/Hg or systolic > 200mm/Hg)
• Stroke with moderate to severe aphasia
• History of three or more falls in past 6 months
• Resident of a long-term care facility
• Other health problem that would prohibit safe participation in the study or home exercise
• Current participation in another OA intervention study
• Currently meeting Department of Health and Human Services physical activity recommendations
• Completed PT for knee OA in the past year
• Unable to speak sufficient English to participate in study activities

Where it is running

• Durham VA Medical Center, Durham, NC — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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