Transcutaneous Auricular Vagus Enhanced Recovery in the NeuroICU

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Acute Neurological Injury, Acute Medical Conditions

In brief

This study will demonstrate the impact of taVNS on reducing adverse events in NeuroICU patients, determine if taVNS reduces length of stay, and quantify the economic benefits of taVNS implementation in a broader neurocritical care population.

Key facts

Study ID

NCT07219108

Run by

Washington University School of Medicine

People needed

160

Starts

2025-09-24

Expected to finish

2027-09-23

Last updated by the study team

2025-10-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18
• Admission to the NeuroICU within 36 hours of onset of an acute medical condition.
• Patient or authorized legal representative should be able to provide consent within 36 hours of ICU arrival
• Presence of at least one predictor of critical illness and/or severe brain / spinal cord injury:
• Glasgow Coma Scale GCS >3 \& <= 12 at admission
• NIH stroke scale of 6 or greater
• Requirement for ongoing mechanical ventilation
• Requirement for ongoing vasopressor support
• Diagnosis of subarachnoid hemorrhage
• Diagnosis of intracerebral hemorrhage with hematoma volume > 5 ml
• Diagnosis of moderate-severe traumatic brain injury (GCS >3 \& <= 12)
• Refractory Status epilepticus requiring continuous sedative infusions

You may not qualify if…

• Systemic immunosuppression
• Receiving ongoing cancer therapy
• Implanted electrical device (e.g., pacemaker, stimulator)
• Bradycardia on admission (Sustained bradycardia on arrival with a heart rate < 50 bpm for >5 minutes)
• Risk of imminent death or limitation of care (e.g., Glasgow Coma Scale of 3, pupillary dilatation)
• Expected ICU stay of less than 72 hours, as determined by attending physician or ICU fellow
• Pregnancy
• COVID-19

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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