Behavioral Safety and Fentanyl Education: BSAFE

Starting soon · Not applicable

Conditions studied: Drug Overdose, Drug Overdose Accidental

In brief

BSAFE is a randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among people who use stimulants who may have unintentional fentanyl use (UFU). It includes an established overdose education curriculum within an Informational-Motivation-Behavior (IMB) model. This study will test the efficacy of BSAFE vs attention-control.

Key facts

Study ID

NCT07219082

Run by

San Francisco Department of Public Health

People needed

160

Starts

2026-06-15

Expected to finish

2030-01-15

Last updated by the study team

2026-06-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 18 years or older,
• Reports intentional cocaine or methamphetamine use >15 of past 30 days,
• Urine positive for cocaine or methamphetamine and negative for opioids/fentanyl prior to enrollment
• Be able to provide the names of at least 2 persons who can consistently locate their whereabouts.
• Reports at least one suspected unintentional fentanyl use event, including unexpected sedation or unexpected fentanyl-positive bodily fluid drug testing result.

You may not qualify if…

• Reports past 30-day intentional use of any opioid or ongoing use of an opioid antagonist (e.g., naltrexone)
• Intends to leave area in coming year,
• Unable to communicate in English or Spanish,
• Any other condition that, in the PI's judgment, interferes with safe study participation or adherence to study procedures.

Where it is running

• San Francisco Department of Public Health — San Francisco, California, United States

Full record on ClinicalTrials.gov

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