Bispectral Monitoring on Mechanically Ventilated Patients

Recruiting now · Not applicable

Conditions studied: Sedation

In brief

The purpose of this study is to determine the difference in the duration of mechanical ventilation, to evaluate the difference in ICU length of stay and to determine the difference in the overall dose of sedation medications between the between participants who were monitored using Bispectral index monitoring (BIS) monitors and those who were not.

Key facts

Study ID

NCT07219069

Run by

The University of Texas Health Science Center, Houston

People needed

30

Starts

2025-11-01

Expected to finish

2026-11-01

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admission to the medical ICU
• Intubated on mechanical ventilation
• On sedation medication infusion

You may not qualify if…

• Patients with a history of chronic opioid use
• Patients with end-stage liver disease at ICU admission (i.e., International normalized ratio >1.5 and not taking warfarin and/or a total serum bilirubin 1.5 times above normal limits)
• Pregnant patients
• Current prisoner
• Refractory shock: Mean arterial blood pressure below 65 millimeters of mercury(65mmHg) despite maximum doses of 3 pressors. Norepinephrine 70mcg/min; vasopressin 0.03 units/min; epinephrine 35mcg/min; dopamine 20mcg/kg/min and phenylephrine 350mcg/min
• Inability to complete the required time for follow-up
• Surgical admission diagnosis
• Patients with skin conditions precluding BIS monitor sensor adherence
• Patients on neuromuscular blockade infusion or benzodiazepine infusion

Where it is running

• Memorial Hermann Cypress Hospital — Cypress, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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