Radiation Therapy (RT) for Parkinson's Disease (PD)
Enrolling by invitation · Not applicable
Conditions studied: Parkinson's Disease
In brief
The purpose of this study is to investigate the use of ultra-low, anti-inflammatory doses of radiation therapy (RT) for the treatment of Parkinson's Disease (PD). In this study, the TrueBeam LINAC utilizes a linear accelerator (LINAC) for the delivery of radiation therapy. Dynamic conformal arc (DCA) therapy will be used to deliver a total of five (5) once-a-day radiation treatments (RT) using DaT-SPECT (Dopamine Transporter-Single-Photon Emission Computed Tomography) and MRI imaging to guide radiation treatment planning.
Key facts
- Study ID
- NCT07218952
- Run by
- Mayo Clinic
- People needed
- 20
- Starts
- 2026-01-20
- Expected to finish
- 2027-10-01
- Last updated by the study team
- 2026-06-16
Who can join
Age: 45 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 45 and ≤ 70 years
- Diagnosis of Parkinson's disease by a Movement Disorder Neurologist
- Confirmation of unilateral Parkinson's disease by Dopamine Transporter (DaT) scan
- A score of 2 or less on the modified Hoehn and Yahr scale
- ECOG Performance Status (PS) ≤ 2 (Appendix I).
- No known genetic causes or predisposition to Parkinson's disease or related diseases.
- Ability to complete questionnaires, neurological exam, and follow-up imaging independently or with assistance
- Ability to provide written informed consent
- Willing to provide mandatory blood samples for correlative research purposes
- Willing to return to enrolling institution for follow-up
You may not qualify if…
- Concomitant dementia diagnosis or concerns of other memory disorder
- Parkinson's Disease medication changes within the last 3 months
- Receipt of radiation therapy for Parkinson's Disease outside Mayo Clinic, Rochester
Where it is running
- Mayo Clinic in Rochester — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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