Phase I Trial of pH Resections of GBM at VA

Starting soon · Phase 1

Conditions studied: Glioblastoma

In brief

Glioblastoma is an infiltrating tumor that is difficult to visualize in surgery and on standard images. A special pH (acid-base) related magnetic resonance imaging (MRI) has been developed to better see infiltrating tumor. In this safety study, the investigators will carry out increased levels of pH based resections of infiltrating tumor to assess the tolerability in VA populations.

Key facts

Study ID

NCT07218367

Run by

VA Office of Research and Development

People needed

12

Starts

2026-07-01

Expected to finish

2031-07-01

Last updated by the study team

2026-02-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to provide written informed consent
• Karnofsky Performance Scale (KPS) of 70 or higher
• Suspected, newly diagnosed or recurrent IDH wild type WHO IV glioblastoma presenting as an intra-axial
• Expansile contrast-enhancing mass without evidence of metastatic disease

You may not qualify if…

• Diagnostic uncertainty such as history of extracranial malignancy or autoimmune disease
• Medical conditions prohibiting anesthesia or surgery
• Tumors involving eloquent brain areas as defined by MRI signal
• primary motor cortex, primary sensory cortex, sensorimotor fibers, primary language areas, arcuate fasciculus

Where it is running

• VA Greater Los Angeles Healthcare System, West Los Angeles, CA — West Los Angeles, California, United States

Full record on ClinicalTrials.gov

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