Pain in Juvenile Arthritis

Recruiting now · Not applicable

Conditions studied: Juvenile Idiopathic Arthritis

In brief

Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disease in children. The main symptoms of JIA, which are often the primary focus of treatment, include joint swelling, stiffness, and tenderness. Additional symptoms can include malaise, fatigue, and pain. However, the exact mechanisms contributing to pain are not yet fully understood. Participants will complete a 2.5-hours study session. In the study session, psychophysical assessments of thermal and pressure stimuli will be performed. In addition, demographic, social, pubertal maturation, and behavioral and psychological factors will be collected via questionnaires. A saliva sample and/or blood draw may occur for the analysis of various immune factors and sex hormones. If a joint aspiration is done as part of their standard of care, we will request a sample of the synovial fluid for analyses of immune, hormonal and/or genetic factors. Participants will have the option to participate in additional optional follow-up study visits (every 3 months, up to 1 year) and to complete monthly surveys asking about their juvenile arthritis.

Key facts

Study ID

NCT07217782

Run by

Washington University School of Medicine

People needed

140

Starts

2025-09-15

Expected to finish

2035-09-01

Last updated by the study team

2026-07-14

Who can join

Age: 9 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age between 9-17
• Males and females
• English speakers
• Able to complete surveys and understand study instructions
• Juvenile arthritis group: diagnosed or suspected of juvenile arthritis
• Control group: healthy

You may not qualify if…

• Pregnancy or breastfeeding
• (Control Group) Diagnosed with a chronic pain condition
• (Control Group) Diagnosed with psychiatric condition including ADHD, anxiety, depression, etc.

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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