Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Major Depressive Disorder (MDD), Suicidal Ideation, Hospitalization in Children
In brief
Evaluate the feasibility, safety, and preliminary efficacy of deep Transcranial Magnetic Stimulation (dTMS) as an adjunctive treatment for adolescents hospitalized with major depressive disorder (MDD).
Key facts
- Study ID
- NCT07217444
- Run by
- Children's Hospital Medical Center, Cincinnati
- People needed
- 60
- Starts
- 2025-11-13
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2026-02-11
Who can join
Age: 14 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Fluent in English and able to volunteer in the informed consent process and provide spontaneous narrative description of key elements, risks, and benefits of the study.
- Aged 14 years to 18 years, inclusive.
- Diagnosis of MDD based on psychologist diagnosis and DSM-5-checklist based interview.
- Symptoms of moderate to severe depression according to Hamilton Depression Rating Scale Score > 20.
- Participants are not required to discontinue current interventions
You may not qualify if…
- Participation in an investigational drug trial within the past three months.
- Contraindications to Transcranial Magnetic Stimulation including, but not limited to, a history of epilepsy, the presence of metallic foreign bodies, or implanted medical devices (e.g. ventriculoperitoneal shunt, pacemaker, medical pump).
- Actively psychotic (i.e. disorganized, delusional, paranoid, or having hallucinations)
- Actively suicidal (have a suicidal plan and intent and is on 1:1 close observation)
- For female subjects of childbearing potential, a positive urine pregnancy test.
Where it is running
- Cincinnati Childrens Hospital Medical Center — Cincinnati, Ohio, United States (enrolling)
Full record on ClinicalTrials.gov
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