A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
Recruiting now · Phase 3
Conditions studied: Cervical Cancer
In brief
Researchers are looking for new ways to treat metastatic cervical cancer. Cervical cancer is cancer in the cervix, the lower part of the uterus (womb). Metastatic means the cancer has spread to other parts of the body. Researchers want to learn about giving the study medicine sacituzumab tirumotecan (also called sac-TMT or MK-2870) along with pembrolizumab and bevacizumab treatments. Sac-TMT is an antibody drug conjugate, which is a type of medicine that attaches to specific targets on cancer cells and delivers treatment to destroy those cells. The goals of this study are to learn: * About the safety of sac-TMT with pembrolizumab and bevacizumab, and if people tolerate them when given together, and * If people who receive sac-TMT and pembrolizumab, with or without bevacizumab, live longer overall or without their cancer getting worse as compared to those who receive standard treatment
Key facts
- Study ID
- NCT07216703
- Run by
- Merck Sharp & Dohme LLC
- People needed
- 1023
- Starts
- 2026-01-19
- Expected to finish
- 2031-10-29
- Last updated by the study team
- 2026-08-07
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Mount Sinai Braman Comprehensive Cancer Center ( Site 5043) — Miami Beach, Florida, United States (enrolling)
- Mount Sinai Comprehensive Cancer Center ( Site 6000) — Miami Beach, Florida, United States (enrolling)
- Florida Cancer Specialists - East ( Site 7000) — West Palm Beach, Florida, United States (enrolling)
- Winship Cancer Institute of Emory University ( Site 5005) — Atlanta, Georgia, United States (enrolling)
- Nancy N. & J.C. Lewis Cancer and Research Pavillion - Research Department ( Site 6005) — Savannah, Georgia, United States (enrolling)
- TRIALS 365 ( Site 6008) — Shreveport, Louisiana, United States (enrolling)
- Minnesota Oncology Hematology, PA ( Site 8003) — Edina, Minnesota, United States (enrolling)
- Women's Cancer Center of Nevada ( Site 6011) — Las Vegas, Nevada, United States (enrolling)
- Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 6009) — New York, New York, United States (enrolling)
- Oklahoma Cancer Specialists and Research Institute, LLC ( Site 6001) — Tulsa, Oklahoma, United States (enrolling)
- Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8007) — Eugene, Oregon, United States (enrolling)
- Women & Infants Hospital ( Site 6003) — Providence, Rhode Island, United States (enrolling)
- University of Tennessee Medical Center ( Site 6012) — Knoxville, Tennessee, United States (enrolling)
- Texas Oncology - DFW ( Site 8005) — Fort Worth, Texas, United States (enrolling)
- Texas Oncology-The Woodlands ( Site 8000) — The Woodlands, Texas, United States (enrolling)
- Texas Oncology - Northeast Texas ( Site 8002) — Tyler, Texas, United States (enrolling)
- University of Virginia Cancer Center ( Site 5044) — Charlottesville, Virginia, United States (enrolling)
- University of Virginia Cancer Center ( Site 6014) — Charlottesville, Virginia, United States (enrolling)
- Centro de Oncología e Investigación de Buenos Aires ( Site 0107) — Berazategui, Buenos Aires, Argentina (enrolling)
- Instituto de Investigaciones Clinicas Mar del Plata ( Site 0105) — Mar del Plata, Buenos Aires, Argentina (enrolling)
- Fundación Respirar ( Site 0101) — Belgrano, Buenos Aires F.D., Argentina (enrolling)
- Instituto Misionero del Cancer ( Site 0112) — Posadas, Misiones Province, Argentina (enrolling)
- Instituto de Oncologia de Rosario ( Site 0104) — Rosario, Santa Fe Province, Argentina (enrolling)
- Hospital Provincial del Centenario ( Site 0106) — Rosario, Santa Fe Province, Argentina (enrolling)
- Florida Cancer Specialists - South ( Site 7001) — Fort Myers, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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