Zynrelef Versus Adductor Canal Block

Starting soon · Phase 4

Conditions studied: Knee Osteoarthritis, Arthritis Knee

In brief

To compare postoperative MME consumption 72 hours after TKA in patients receiving intraoperative periarticular HTX-011 (Zynrelef) instillation versus adductor canal block.

Key facts

Study ID: NCT07216586
Run by: University of Miami
People needed: 120
Starts: 2027-01-01
Expected to finish: 2028-01-01
Last updated by the study team: 2026-06-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Patients > 18 years of age
Patients undergoing primary, unilateral total knee arthroplasty
Ability to provide informed consent

You may not qualify if…

Individuals under the age of 18
Pregnant women
Prisoners
Adults unable to consent
American Society of Anesthesiologists Physical Status score greater than 3
Patients taking any of the following medications before surgery:
Long-acting opioids within 3 days
Any opioids taken within 24 hours
Bupivacaine HCL within 5 days
Chronic opioid use or patients with known or suspected daily use of opioids for seven or more consecutive days within 6 months before their scheduled surgery
Illicit drug use determined by social history
Alcohol abuse determined by a CAGE Substance Abuse Screening Tool Score of at least two or greater
Patients with a known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to any local anesthetic agent of the amide-type, NSAIDs, or to any of the other components of ZYNRELEF
Patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients

Where it is running

University of Miami — Miami, Florida, United States

Full record on ClinicalTrials.gov

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