Intent of Surgery for IPMN

Recruiting now

Conditions studied: Intraductal Papillary Mucinous Neoplasm

In brief

This multicenter retrospective observational cohort study seeks to: 1. Classify surgical intent in patients with resected Intraductal Papillary Mucinous Neoplasms (IPMN) and quantify the proportion of IPMN-associated cancers diagnosed as overt pancreatic cancer with incidental IPMN association on pathology. 2. Compare clinicopathologic features and outcomes between surveillance-detected and incidentally detected IPMN-derived pancreatic cancers. 3. Revise and redefine risk features limited to patients undergoing surgery for IPMN-related indications, identifying optimal predictors of malignant IPMN (high-grade dysplasia or invasive cancer).

Key facts

Study ID

NCT07216521

Run by

NYU Langone Health

People needed

2000

Starts

2025-09-15

Expected to finish

2025-12-01

Last updated by the study team

2025-10-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients (18 years old of greater) who underwent surgical resection for IPMN (including low-, high-grade dysplasia, or invasive carcinoma) between July 1, 2015 and July 1, 2025.

You may not qualify if…

• Patients with concomitant pancreatic ductal adenocarcinoma (PDAC)

Where it is running

• Mayo Clinic — Phoenix, Arizona, United States (enrolling)
• Johns Hopkins University — Baltimore, Maryland, United States (enrolling)
• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
• Mayo Clinic — Rochester, Minnesota, United States (enrolling)
• NYU Langone Health — New York, New York, United States (enrolling)
• Memorial Sloan Kettering — New York, New York, United States (enrolling)
• Duke University — Durham, North Carolina, United States (enrolling)
• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
• Nanjing University — Nanjing, China (enrolling)
• Heidelberg University — Heidelberg, Germany (enrolling)
• San Raffaele Hospital — Milan, Italy (enrolling)
• Padua University — Padua, Italy (enrolling)
• University of Amsterdam — Amsterdam, Netherlands (enrolling)
• University of Utrecht — Utrecht, Netherlands (enrolling)

Full record on ClinicalTrials.gov

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