K08 VR Fear Conditioning
Enrolling by invitation · Not applicable
Conditions studied: Anxiety and Fear, PTSD, Veteran
In brief
The goal of this clinical trial is to learn how people respond to fear-related experiences in a virtual reality (VR) environment. The study will also look at how brain activity and body responses are connected to learning and memory of fear. To do so, we recruit individuals who are already implanted with a Responsive Neurostimulator (RNS) device for the treatment of epilepsy. This research may help improve our understanding of anxiety disorders and how to better treat them in the future. The main questions it aims to answer are: 1) How do people learn to associate certain cues in VR with feelings of fear or safety? 2) What brain and body responses happen during fear learning? Participants will: 1) Wear a virtual reality headset and experience different environments and sounds, 2) Have their brain activity, heart rate, and sweating measured, and 3) Receive safe, mild electrical pulses through the RNS device during the study to help study fear learning. Participants will attend one or more study sessions, each lasting about 3-4 hours.
Key facts
- Study ID
- NCT07216222
- Run by
- University of California, Los Angeles
- People needed
- 70
- Starts
- 2025-03-01
- Expected to finish
- 2030-02-28
- Last updated by the study team
- 2025-10-14
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Male
- Female
- Between 18 and 70 years of age
- Adequate visual and auditory acuity to allow neuropsychological testing
- Have undergone surgical placement of NeuroPace RNS System for the treatment of epilepsy or post-traumatic stress disorder
You may not qualify if…
- History of traumatic brain injury
Where it is running
- UCLA Semel Institute for Neuroscience and Human Behavior — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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