Predictive Value of Lung Ultrasound for Respiratory Decompensation in Late Preterm Neonates

Recruiting now

Conditions studied: Pre-Term, Respiratory Distress of Newborn, Premature

In brief

Respiratory morbidity presents a significant clinical challenge in the neonatal period, and an individual patient's clinical course is often difficult to predict. This is especially true for late-preterm infants, who share some of the same risks of premature babies in terms or respiratory morbidity, but whose births may not always be attended by a neonatologist, or who may be born at hospitals with lower level Neonatal Intensive Care Units (NICUs) and require transfer if they decompensate. With this study, the aim is to 1) determine the efficacy of early point of care lung ultrasound (LUS) to predict respiratory decompensation in the first 48 hours of life in late preterm infants and 2) to compare the performance of three lung ultrasound scoring systems, 3 type-of-lung, high risk pattern and total LUS scoring systems.

Key facts

Study ID: NCT07216053
Run by: Hackensack Meridian Health
People needed: 300
Starts: 2025-11-06
Expected to finish: 2027-11-01
Last updated by the study team: 2026-05-22

Who can join

Age: 1 and older, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Inborn infants born between 34w0d and 36w6d gestational age
In RA or 1 Litre per minute 1LPM NC (room air (RA) or nasal cannula (NC))
Admitted to NICU or Well Baby Nursery (WBN)

You may not qualify if…

Patients born <34 weeks or >36w6d
Major genetic anomaly or syndromic condition
Cardiac or pulmonary structural defects
Cord pH <7.0 or 5 minute APGAR 5 or less
Suspected fetal hemorrhage or other source of significant anemia at birth

Where it is running

Hackensack Univeristy Medical Center — Hackensack, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

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