A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Obesity, Overweight, Diabetes Mellitus, Type 2

In brief

The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with obesity or overweight and with type 2 diabetes. Participation in the study will last about 48 weeks.

Key facts

Study ID

NCT07215559

Run by

Eli Lilly and Company

People needed

200

Starts

2025-10-16

Expected to finish

2027-05-01

Last updated by the study team

2026-07-17

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have type 2 diabetes
• Have an HbA1c ≥7.5% to ≤10.5% at screening
• Have been treated with any of the following, alone or in combination, for at least 3 months prior to screening
• Diet and exercise
• Stable dose of metformin
• Sodium-glucose cotransporter-2 (SGLT2) inhibitor
• Have had a stable body weight (<5% body weight gain and/or loss) for the 3 months prior to screening
• Have a BMI of 27 or greater at screening

You may not qualify if…

• Have any form of diabetes other than type 2 diabetes
• Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening
• Have any of the following cardiovascular conditions within 3 months prior to screening:
• acute myocardial infarction
• cerebrovascular accident (stroke)
• unstable angina, or
• hospitalization due to congestive heart failure
• Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years, exceptions include
• basal or squamous cell skin cancer
• in situ carcinomas of the cervix, or
• in situ prostate cancer
• Have been prescribed any of the following receptor agonists (RA) or their combination for any indication within the last 6 months:
• amylin RA
• dual amylin and calcitonin RA
• glucagon-like peptide-1 receptor (GLP-1) RA
• glucose-dependent insulinotropic peptide (GIP)/GLP-1 RA
• GLP-1/glucagon (GCG) RAs, or
• GIP/GLP-1/GCG RAs
• Have used excluded antihyperglycemic medications within 3 months prior to screening (including, but not limited to, sulfonylureas, dipeptidyl peptidase-4 inhibitors, alpha-glucosidase inhibitors, thiazolidinediones, and meglitinides
• Have used insulin for diabetic control within the prior year (short term use in certain situations allowed

Where it is running

• Mgcendo Llc — San Juan, Puerto Rico (enrolling)
• Synexus Clinical Research US, Inc. — Phoenix, Arizona, United States (enrolling)
• Pima Heart — Tucson, Arizona, United States (enrolling)
• Precision Clinical Research — Sunrise, Florida, United States (enrolling)
• SKY Clinical Research Network Group-Brown — Atlanta, Georgia, United States (enrolling)
• Teak Research Consults — Lawrenceville, Georgia, United States (enrolling)
• AGILE Clinical Research Trials, LLC — Sandy Springs, Georgia, United States (enrolling)
• Pivotal Research Solutions — Stonecrest, Georgia, United States (enrolling)
• Rophe Adult and Pediatric Medicine/SKYCRNG — Union City, Georgia, United States (enrolling)
• Vector Clinical Trials — Las Vegas, Nevada, United States (enrolling)
• Premier Research — Trenton, New Jersey, United States (enrolling)
• PriMED Clinical Research — Dayton, Ohio, United States (enrolling)
• Mercy Family Clinic — Dallas, Texas, United States (enrolling)
• Velocity Clinical Research, Dallas — Dallas, Texas, United States (enrolling)
• Biopharma Informatic, LLC — Houston, Texas, United States (enrolling)
• PlanIt Research, PLLC — Houston, Texas, United States (enrolling)
• Research Physicians Network, LLC — Houston, Texas, United States (enrolling)
• Aavon Clinical Trials — Richmond, Texas, United States (enrolling)
• Consano Clinical Research, LLC — Shavano Park, Texas, United States (enrolling)
• Texas Valley Clinical Research — Weslaco, Texas, United States (enrolling)
• Kalo Clinical Research — West Valley City, Utah, United States (enrolling)
• Eastern Virginia Medical School (EVMS) Medical Group — Norfolk, Virginia, United States (enrolling)
• Clinical Research Partners, LLC — Richmond, Virginia, United States (enrolling)
• Northwest Clinical Research Center — Bellevue, Washington, United States (enrolling)
• Rainier Clinical Research Center — Renton, Washington, United States (enrolling)

Full record on ClinicalTrials.gov

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