Neuropsychiatric Outcomes and Disrupted Sleep Following Acquired Brain Injury

Recruiting now

Conditions studied: Acquired Brain Injury (Including Stroke)

In brief

The two most common causes of brain injury are stroke and trauma. Both sleep and mental health problems are common after brain injury; we will investigate whether there is a relationship between poor sleep quality and worse mental health in this group. We will also follow patients up, at approximately three-monthly intervals until one year after injury, to see how sleep and mental health symptoms change over time and with recovery. We will assess sleep in detail using questionnaires, a sleep monitor worn on the wrist, a portable brain activity sensor, and a sleep mat. We will assess mental health (neuropsychiatric) symptoms using questionnaires. Participants will be asked to complete these assessments at baseline and at approximately 3-monthly intervals until they reach 12 months post-injury. This data will allow us to explore the types of sleep disruption seen after brain injury and examine the association between sleep and mental health symptoms.

Key facts

Study ID: NCT07215195
Run by: University of Oxford
People needed: 150
Starts: 2025-10-10
Expected to finish: 2027-11-30
Last updated by the study team: 2026-07-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Willing and able to give informed consent for participation in the study.
Aged 18 years or above.
At least one week, but less than 12 months post-injury
Clinical diagnosis of acquired brain injury (stroke, haemorrhage or traumatic).
Participants with Traumatic Brain Injury will have a Mild (probable) or Moderate-severe (definite) brain injury according to the Mayo classification
Participants must be willing to consent to us contacting their general practitioner (GP) or direct care team if we have concerns about their mental health

You may not qualify if…

Brain injury not caused by trauma, haemorrhage or stroke
Previous brain injury.
Other relevant neurological conditions which could affect outcome measures (e.g., Parkinson's or Alzheimer's disease)
No stable and suitable place to sleep

Where it is running

Oxford Centre for Integrative Neuroimaging (WIN) FMRIB, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU — Oxford, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.