Development and Investigation of the ApneaTheraPlay
Starting soon · Not applicable
Conditions studied: Apnea, Obstructive, Exercise Addiction, Physiotherapy and Rehabilitation
In brief
Obstructive Sleep Apnea Syndrome (OSAS) is commonly treated with CPAP devices, but adherence rates are low. Exercise has been shown to strengthen respiratory muscles, improve upper airway function, and enhance sleep quality. However, most studies have examined only single or dual exercise protocols, and there is little evidence regarding integrated programs with four exercise types or their effects when performed directly before sleep. This project aims to develop and evaluate ApneaTheraPlay (ATP), a digital gamified video-based exercise platform combining respiratory, aerobic, strengthening, and oropharyngeal exercises. The randomized controlled, double-blind study will allocate participants into three groups: ATP, a structured pre-sleep exercise group (SPEG), and a control group (CG). Intervention groups will exercise three times per week for 12 weeks, while the control group will only keep a physical activity diary.
Key facts
- Study ID
- NCT07214636
- Run by
- Medipol University
- People needed
- 54
- Starts
- 2026-07-28
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-07-28
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 18-65 years of age
- Individuals diagnosed with mild, moderate, or severe OSAS (AHI 5-30 events/hour) based on laboratory diagnostic polysomnography assessments
- Individuals diagnosed by a pulmonologist within the last year and who have started CPAP therapy for at most 12 months and who are regular users
- Those with habitual snoring
- All participants in the exercise group must have or have access to a phone, tablet, or computer compatible with SMART technologies using the exercise system app
- Participants must have sufficient physical function to follow the exercise instructions
- Familiarity with mobile health applications, as assessed by the VAS, and a willingness to participate in these exercises of >7
- Not having participated in physiotherapy-based interventions targeting OSAS in the last 3 months
- A score of 68 or higher on the System Usability Scale (SUS)
You may not qualify if…
- • BMI > 40 kg/m2
- Serious drug or alcohol abuse
- Regular use of sedatives, muscle relaxants, or opioids that may affect sleep patterns or exercise performance
- Pregnancy or postpartum (<6 months) due to hormonal effects on sleep and respiratory function
- Any medical contraindication to physical activity (unstable coronary disease, decompensated heart failure) according to the American College of Sports Medicine (ACSM) exercise guidelines (American College of Sports Medicine, 2021)
- History of stroke
- Presence of any significant respiratory, neuromuscular, or other disorder causing hypercapnia
- Systemic disease associated with an inflammatory entity (e.g., arthritis, sarcoidosis, vasculitis, lupus)
- Craniofacial deformity
- Presence of secondary respiratory diseases such as severe upper airway obstruction or COPD
- Presence of dysphagia
- Presence of a frenulum restricting tongue movement
Where it is running
- Istanbul Medipol Universty — Istanbul, Göztepe Neighborhood, Turkey (Türkiye)
Full record on ClinicalTrials.gov
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