Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Post Concussive Syndrome

In brief

The purpose of this study is to evaluate how hyperbaric oxygen therapy (HBOT) may affect cognitive functioning, post-traumatic stress disorder (PTSD), depression, anxiety, and overall quality of life in veterans. 1. Does Hyperbaric Oxygen Therapy improve cognitive functioning, psychological well-being, and quality of life among veterans, as measured by pre-and post-treatment scores? 2. To what extent does Hyperbaric Oxygen Therapy improve cognitive functioning, psychological well-being, and qualify of life among veterans, after controlling for demographic characteristics.

Key facts

Study ID

NCT07214415

Run by

Summit Hyperbarics and Wellness

People needed

54

Starts

2025-10-01

Expected to finish

2026-09-15

Last updated by the study team

2025-10-09

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 18 years of age.
• Veteran status
• Clinically diagnosed with a mTBI, PTSD, Anxiety, or Depression disorder by meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and by a qualified and trained professional.
• The subject is willing and able to read, understand, and sign an informed consent. Additionally, the subject has clear consciousness and the ability to express self-feelings independently.
• Exposed to at least one trauma-focused therapy or evidence-based psychotherapeutic treatment, such as prolonged exposure therapy, EMDR, or CBT, to name a few.
• Completed cognitive and psychological measurements.
• Clinical diagnoses cause significant impairment in social or occupational functioning or some other functional capacity.
• Sexually active female participants of childbearing potential and sexually active male participants with female partners of childbearing potential must agree to use an acceptable method of contraception for the duration of the study and for 30 days following the final HBOT session.
• Stability on any current psychoactive medications (antidepressants, anti-anxiety medications, antipsychotics, stimulants, and mood stabilizers).

You may not qualify if…

• Untreated pneumothorax
• History of spontaneous pneumothorax
• Severe sinus infection
• Upper respiratory infection
• Asymptomatic pulmonary lesions on chest x-ray
• Uncontrollable high fever (greater than 39C)
• History of chest or ear surgery
• Congenital spherocytosis
• Any anemia or blood disorder
• Any convulsive disorder
• History of optic neuritis or sudden blindness
• Middle ear infection
• Diabetes mellitus (insulin therapy)
• The subject is pregnant or lactating
• Nicotine use/substance use/addiction
• Acute Hypoglycemia
• Diagnosed Chronic Obstructive Pulmonary Disease (COPD) and Emphysema
• Presenting with symptoms of cough, congestion, vomiting, diarrhea, or open wounds.
• Active malignancy
• Current manic, delusional, or psychotic episodes
• Serious/current suicidal ideations
• Severe or unstable physical disorders or major cognitive deficits
• Inability to attend scheduled clinic visits or comply with study protocols.
• Treated with HBOT for any reason prior to study enrollment.
• Non-English speakers

Where it is running

• Summit Hyperbarics and Wellness — Boise, Idaho, United States (enrolling)

Full record on ClinicalTrials.gov

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