REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Symptomatic Venous Thromboembolism (VTE)
In brief
This study is researching an experimental drug called REGN7508 (called "study drug") and how it compares against another treatment called Acetylsalicylic Acid (ASA). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) and other related diseases after total knee replacement surgery compared to acetylsalicylic acid. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)
Key facts
- Study ID
- NCT07213778
- Run by
- Regeneron Pharmaceuticals
- People needed
- 2000
- Starts
- 2025-11-24
- Expected to finish
- 2027-07-16
- Last updated by the study team
- 2026-07-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- PMSI Emergency Medicine Institute — Chisinau, Moldova (enrolling)
- Eisenhower Medical Center — Rancho Mirage, California, United States (enrolling)
- Sky Ridge Medical Center — Lone Tree, Colorado, United States (enrolling)
- South Florida Joint Replacement Center — Deerfield Beach, Florida, United States (enrolling)
- Medical Research of Westchester - MPLUS Research Network — Miami, Florida, United States (enrolling)
- Phoenix Clinical Research — Tamarac, Florida, United States (enrolling)
- Endeavor Health — Skokie, Illinois, United States (enrolling)
- The Orthopaedic Research Foundation, Inc. — Indianapolis, Indiana, United States (enrolling)
- NextStage Clinical Research, St. Francis Medical Park — Wichita, Kansas, United States (enrolling)
- Velocity Clinical Research, Annapolis — Annapolis, Maryland, United States (enrolling)
- Sinai Hospital of Baltimore, Inc. — Baltimore, Maryland, United States (enrolling)
- Tufts Medical Center — Boston, Massachusetts, United States (enrolling)
- Boston Medical Center — Boston, Massachusetts, United States (enrolling)
- Holy Name Medical Center — Teaneck, New Jersey, United States (enrolling)
- University of Rochester Medical Center — Rochester, New York, United States (enrolling)
- Eximia Equihealth Research-Raleigh. LLC — Raleigh, North Carolina, United States (enrolling)
- The Vein and Vascular Center at Raleigh Radiology — Raleigh, North Carolina, United States (enrolling)
- Coastal Vascular Institute, PA — Wilmington, North Carolina, United States (enrolling)
- University of Cincinnati — Cincinnati, Ohio, United States (enrolling)
- The Ohio State University Wexner Medical Center — Columbus, Ohio, United States (enrolling)
- Ohio Clinical Trials — Columbus, Ohio, United States (enrolling)
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States (enrolling)
- HD Research - Memorial Hermann Village — Houston, Texas, United States (enrolling)
- NextStage Clinical Research, All American Orthopedics and Sports Medicine — Houston, Texas, United States (enrolling)
- Flourish Research - San Antonio (Formerly Clinical Trials of Texas) — San Antonio, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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