Quantification of Progenitor Cell Circulation Following Vascular Resistance Exercise Using Delfi Tourniquet System

Running, not enrolling · Not applicable

Conditions studied: Blood Flow Restriction (BFR) Training Effects

In brief

The purpose of this observational study is to examine how slowing down blood flow to the legs- a practice called blood flow restriction (BFR)- during exercise by applying compression to the legs affects the way stem cells are released into the blood stream. This will be determined by drawing 6 cubic centimeters (ccs) of blood immediately post-exercise after the Delfi Personalized Tourniquet System (PTS) has been removed. 6 ccs of blood will also be taken prior to exercise and at the 20-, 40-, and 60-minute marks after exercise. The main question of this study is: • Will the levels of stem cells extracted before and after exercise be the same if blood flow is restricted during exercise? In this study, participants will undergo the following: * 6 ccs of blood extracted from the forearm prior to exercise to establish a baseline * 3 exercises- seated leg extension, semi-reclined leg press, and seated hamstring curl- consisting of 4 sets of 30-15-15-15 repetitions per exercise; resistance will be set to 30% of one-rep maximum (1-RM) * Additional 6 cc blood draws will be performed immediately post-exercise and after 20, 40, and 60 minutes have elapsed

Key facts

Study ID

NCT07213726

Run by

Andrews Research & Education Foundation

People needed

15

Starts

2022-08-16

Expected to finish

2026-11-20

Last updated by the study team

2025-12-08

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Volunteer population of healthy males and females aged 18-45.
• Subjects consent to attending a total of 14 visits over a time span of seven to nine weeks. The breakdown of the 14 visits is as follows: 1 familiarization session, 12 experimental testing sessions, 1 final session.

You may not qualify if…

• Volunteers who have medical history involving one or more of the following medical conditions:
• Diabetes
• Uncontrolled hypertension
• Autoimmune disorders
• Blood disorders
• Ongoing infectious disease
• Cancer
• Any disorder requiring immunosuppression treatment
• Steroid usage
• Significant cardiovascular, pulmonary, hepatic, or renal disease.
• Volunteers where 20 minutes of intense exercise is contra-indicated will also be excluded from the study.
• Positive pregnancy test

Where it is running

• Andrews Institute for Orthopaedics & Sports Medicine — Gulf Breeze, Florida, United States

Full record on ClinicalTrials.gov

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