Remimazolam vs Propofol in Laser Burn Cases

Recruiting now · Phase 4

Conditions studied: Burn Scar, Hypertrophic Scarring, Procedural Sedation

In brief

This randomized, single-blind, crossover study compares remimazolam and propofol for monitored anesthetic care during fractional ablative CO₂ laser therapy for burn scars. The primary aim is to assess incidence of respiratory depression, defined as a need for advanced airway maneuvers (jaw thrust/chin lift, insertion of oral or nasal airway, or bag mask ventilation), and hypopnea (respiratory rate \< 8).

Key facts

Study ID

NCT07213544

Run by

Medical University of South Carolina

People needed

136

Starts

2025-11-12

Expected to finish

2027-01-01

Last updated by the study team

2025-11-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Undergoing both outpatient Session #1 and Session #2 of fractional ablative CO2 laser therapy

You may not qualify if…

• History of previous fractional ablative laser therapy for burn scar
• Procedure expected to last longer than 30 minutes
• Allergy such as dextran 40 or contraindication to either of the study drugs
• Pregnant and/or breastfeeding
• Subjects who are unable to or choose not to give informed consent

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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