High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy
Recruiting now · Phase 2/Phase 3
Conditions studied: Analgetic, Lung Cancer (NSCLC), Video Assisted Thoracic Surgery (VATS), Glucocorticoid
In brief
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy. The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale
Key facts
- Study ID
- NCT07213375
- Run by
- Rigshospitalet, Denmark
- People needed
- 80
- Starts
- 2025-09-01
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2026-01-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 year
- Able to understand written and spoken Danish language
- PCS ≥20
- Signed written informed consent form.
- Patient planned to elective VATS lobectomy/segmentectomy
You may not qualify if…
- Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, ex-cluding inhaled steroids.
- Individuals with diabetes requiring insulin treatment.
- Pregnant or breastfeeding patients.
- Patients with known allergies to the study drug.
- Individuals with mental disabilities that may impair their capacity to provide informed consent or compromise the validity of data collection.
- Patients with diagnosed schizophrenia, active psychosis, bipolar disorder, or a history of ongoing treatment with antipsychotic and/or antidepressant medications.
- Individuals with altered pain perception due to other conditions or injuries, such as spi-nal cord or brain injuries, severe polyneuropathies, or neurological disorders.
- Regular users of opioid medications.
- Patients requiring reoperation within the first two postoperative days.
- Individuals undergoing conversion to a surgical procedure other than VATS lobecto-my/segmentectomy.
Where it is running
- Department for Cardiothoracic Surgery, Rigshospitalet — Copenhagen, Copenhagen, Denmark (enrolling)
Full record on ClinicalTrials.gov
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