CHAMPION: Combining HIV And Meth Prevention and Treatment Interventions Optimized for HIV-Negative MSM
Starting soon · Not applicable
Conditions studied: PrEP Adherence, Methamphetamine Use Disorder, HIV
In brief
The goal of this randomized controlled trial is to pilot test new mobile health (mHealth) interventions to improve PrEP adherence among HIV-negative men who have sex with men (MSM) with mild to moderate methamphetamine use disorder (MUD). The CHAMPION intervention combines two mHealth tools-PrEPAPP and CBT4CBT-to address both HIV prevention and MUD treatment needs in this population. The study's specific aims are: * To evaluate the feasibility and acceptability of the CHAMPION intervention based on treatment retention and engagement rates. * To examine the preliminary efficacy the CHAMPION intervention to improve PrEP adherence, as measured by dried blood spot (DBS) tests compared to the waitlist control group.
Key facts
- Study ID
- NCT07213258
- Run by
- University of California, San Diego
- People needed
- 100
- Starts
- 2025-10-22
- Expected to finish
- 2026-08-15
- Last updated by the study team
- 2025-10-08
Who can join
Age: 18 and older, up to 40. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- HIV-negative
- Cis-gender male
- Age 18-40 years old
- Mild or moderate MUD (by DSM-5 SCID criteria)
- Anal intercourse with one or more male partners in the past 6 months
- Started daily oral PrEP more than 30 days ago and self-reported not always taking PrEP as prescribed in the past 30 days (consistent with PrEP It! inclusion criteria)
- Willingness to participate in an mHealth study with a 6-month follow-up
- Residing in San Diego or San Francisco County
You may not qualify if…
- Residing outside of San Diego or San Francisco County
- Any condition that, in the principal investigator's judgment interferes with safe study participation or adherence to study procedures
- Not able/willing to complete virtual/remote visits
- Not willing to learn to self-collect dried blood spots using a finger stick
Where it is running
- Center on Substance Use and Health — San Francisco, California, United States
Full record on ClinicalTrials.gov
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