Percutaneous Blockade of the Stellate Ganglion in Electrical Storm
Recruiting now · Phase 4
Conditions studied: Electrical Storm, Stellate Ganglion Block, Ventricular Arrhythmia
In brief
There is no randomized clinical study in the literature that evaluated the efficacy and safety of the stellate ganglion infiltration procedure in patients with electrical storm. So far, case reports and retrospective studies suggest that such a strategy should be considered in cases refractory to initial therapy. In this scenario, the European and American guidelines for the treatment of ventricular arrhythmias recommend autonomic modulation in this setting, but only with a level of recommendation IIb (1,2). This project aims to evaluate the effect of stellate ganglion infiltration in patients with electric storm refractory to initial clinical measures. It is a randomized clinical trial where patients will receive treatment with a lidocaine and bupivacaine anesthetic solution or no intervention. The effect of the intervention will be considered positive when there is a reduction of arrhythmic events of at least 50% in the 12 hours immediately after.
Key facts
- Study ID
- NCT07211347
- Run by
- University of Sao Paulo General Hospital
- People needed
- 64
- Starts
- 2025-06-06
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2025-10-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients over 18 years old with structural heart disease and a diagnosis of refractory electrical storm, or those who require discontinuation of antiarrhythmics due to adverse events or contraindications to standard therapy.
You may not qualify if…
- Patients under 18
- History of heart transplant or prior cardiac denervation surgery
- Anatomical contraindications for the procedure (prior neck surgery, burns, large scars, or thyroid goiter).
- Genetically related polymorphic VT
- End-stage renal disease on dialysis
Where it is running
- Clinical Research Center of the Heart Institute - University of São Paulo — São Paulo, São Paulo, Brazil (enrolling)
Full record on ClinicalTrials.gov
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