Acquired Dyslexia Modeling and Treatment

Recruiting now · Not applicable

Conditions studied: Stroke, Dyslexia, Acquired

In brief

This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired dyslexia and its treatment. The aim is to determine whether there is an advantage to receiving the treatment the model predicts to be advantageous compared to the alternative treatment. All participants will receive two full rounds of treatment. A round of treatment will consist of either phonomotor treatment (PMT) or semantic feature analysis (SFA) for 60 hours, distributed over 5 days a week for 2 hours a day.

Key facts

Study ID

NCT07209488

Run by

Rutgers, The State University of New Jersey

People needed

12

Starts

2025-12-03

Expected to finish

2026-09-01

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Fluent in English as a first language pre-stroke by self report.
• Normal or corrected-to-normal vision.
• Normal or aided hearing.
• Left hemisphere ischemic or hemorrhagic stroke (as verified by a structural brain scan).
• Impaired reading as confirmed by significant impairment in the Basic Skills cluster of the Woodcock Reading Mastery Test - III.

You may not qualify if…

• Diagnosed pre-stroke neurological disease affecting the brain other than left hemisphere stroke.
• Severe apraxia of speech (determined by consensus judgment among speech-language pathologists).
• History of learning disabilities such as developmental dyslexia or current self-reported major psychiatric disorders.
• Inability to undergo, or provide a copy of, a post-stroke brain imaging scan.

Where it is running

• Florida State University — Tallahassee, Florida, United States (enrolling)
• Johns Hopkins University School of Medicine — Baltimore, Maryland, United States (enrolling)
• Kessler Foundation — West Orange, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

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