Functional Inspiratory Versus Expiratory Muscle Electrical Stimulation on Weaning Outcomes in Mechanically Ventilated Patients

Starting soon · Not applicable

Conditions studied: Icu

In brief

The Goal of This Clinical Trail is * To find out the difference in the effect of inspiratory muscle functional electrical stimulation and expiratory muscle functional electrical stimulation on weaning outcomes mechanically ventilated patients. * To investigate the effect of inspiratory muscle functional electrical stimulation and expiratory muscle functional electrical stimulation on Laboratory investigation (Arterial Blood Gases). * To investigate the effect of inspiratory muscle functional electrical stimulation and expiratory muscle functional electrical stimulation on Sonar parameters (Diaphragmatic excursion, Diaphragmatic muscle fractional thickness in the end of inspiration and the end of expiration and abdominal muscles wall thickness). To evaluate the effect of inspiratory muscle functional electrical stimulation and expiratory muscle functional electrical stimulation on (ICU length of stay and Spontaneous Breathing Trail (SBT)).

Key facts

Study ID

NCT07204821

Run by

Beni-Suef University

People needed

48

Starts

2026-06-15

Expected to finish

2026-09-01

Last updated by the study team

2026-06-03

Who can join

Age: 45 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All mechanically ventilated patients will be:
• Their ages range from 45 to 65 years.
• Their BMI is from 25-29.9kg/m2.
• Mechanically ventilated for at least 24 hours.
• They all have hypoxemic respiratory failure
• Glasgow coma score (GCS) ranged from 6 to 12.
• Richmond Agitation-Sedation Scale score: -2 to +2
• Patients and their relatives had written informed consent.

You may not qualify if…

• Hemodynamically unstable patients.
• Patients with rib fractures.
• Patients with implanted pacemaker.
• Obese (BMI greater than 30 kgm2).
• Tachycardia.
• Uncontrolled hypertension.
• History of neuromuscular disease at admission.
• Spinal injuries.
• Inability to trigger mechanical ventilation
• Pregnancy
• An anticipated stay on the ventilator <72 h at the time of study
• Patients who cannot attach electrodes due to local skin damage or infection
• Patients with Severe intestinal gas accumulation, structural abnormalities, and other reasons that prevent ultrasound detection of diaphragm movement.
• Congenital myopathies or neuropathies, and contraindications for expiratory muscle FES (cardiac pacemaker, refractory epilepsy, recent (< 4 weeks) abdominal surgery).
• Patients with unrelieved pneumothorax and restricted diaphragm movement disorders.
• Chest or diaphragm malformation

Where it is running

• Beni-Suef University, Beni-Suef — Cairo, Egypt

Full record on ClinicalTrials.gov

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