A Three-Phase Contralateral Comparison of Ray-Tracing Guided LASIK Versus Three Other Refractive Surgery Platforms to Correct Myopia or Myopia With Astigmatism

Recruiting now · Not applicable

Conditions studied: Myopia, Astigmatism

In brief

This purpose of this study is to compare a new form of LASIK called Ray Tracing Guided LASIK to 3 other forms of corneal refractive surgery: 1. KLEx (KeratoLenticule Extraction) using the Zeiss Visumax 800 Laser, 2. WFO LASIK (Wavefront Optimized LASIK) using the Alcon EX500 Laser, and 3. Topography Guided LASIK (Contoura LASIK) also using the Alcon EX500 Laser.

Key facts

Study ID: NCT07201298
Run by: Hoopes Vision
People needed: 120
Starts: 2025-09-01
Expected to finish: 2029-09-01
Last updated by the study team: 2025-10-01

Who can join

Age: 22 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Age 22-50 at the time of consent
Diagnosis of myopia or myopia with astigmatism with Preoperative manifest spherical equivalent refraction of ≥ -2.00 and ≤ -9.00 D (-2.00 D through -9.00 D)
Preop Spherical component of ≥ -2.00 and ≤ -8.00 D (-2.00 D through -8.00 D)
Refractive Cylinder of ≤ -3.00 D (0.00 through -3.00 D)
BCVA of 20/20 or better in each eye (83 or more letters on the ETDRS Chart)
Subjects must have a stable refraction which is defined as a change in spherical equivalent no greater than 0.50 D comparing the screening visit manifest refraction to a previous refraction, spectacle Rx, or contact lens Rx, 12 months or older.
Subjects who are contact lens wearers must discontinue the use of soft lenses (spherical or toric) for at least 5 days and hard or gas-permeable lenses for at least 4 weeks prior to the preoperative screening evaluation. Hard or gas-permeable lens wearers must not return to contact lens use before surgery. Soft lens wearers may resume contact lens wear after all preoperative testing is completed, but must discontinue lens use at least 5 days before surgery.
Acceptable preoperative tomography and examination results for refractive procedures as determined by the Principal Investigator.
Surgical plan includes treatment target for emmetropia in both eyes, and no monovision.
Subject is capable and willing to use postoperative medications as prescribed.
Subject has ability to successfully complete all preoperative and postoperative questionnaires, testing, and exam visits.
Subject is willing and able to return for all postoperative examinations.

You may not qualify if…

Clinically significant dry eye on clinical examination, as determined by the investigator
Irregular astigmatism, keratoconus, keratoconus suspect, or abnormal corneal tomography
History of corneal dystrophies or guttata
History of herpetic keratitis or active disease
History of prior refractive surgery
History of glaucoma or glaucoma suspect
History of uncontrolled diabetes, unstable hypertension, or unstable autoimmune disease.
Females who are pregnant, breastfeeding, or intend to become pregnant any time during the study as determined by verbal inquiry.
The Principal Investigator has determined the subject not to be a good candidate for the study.

Where it is running

Hoopes Moshirfar Research Center — Draper, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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