A Trial Evaluating Brelovitug (BJT-778) vs Bulevirtide for the Treatment of Chronic Hepatitis Delta Infection (AZURE-2)
Recruiting now · Phase 3
Conditions studied: Chronic Hepatitis D Infection
In brief
This is a Phase 3, global, randomized, open-label, multicenter, trial evaluating brelovitug (BJT-778) vs bulevirtide for the treatment of chronic hepatitis delta infection (CHD). The main goal of this study is to test the effectiveness of brelovitug compared to bulevirtide as a long-term treatment in patients with chronic HDV infection.
Key facts
- Study ID
- NCT07200908
- Run by
- Mirum Pharmaceuticals, Inc.
- People needed
- 172
- Starts
- 2025-08-27
- Expected to finish
- 2029-09-30
- Last updated by the study team
- 2026-06-15
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Medical University of Graz — Graz, Austria (enrolling)
- Universitätsklinikum St. Pölten — Sankt Pölten, Austria (enrolling)
- Fakultni Nemocnice Brno — Brno, Brno, Czechia (enrolling)
- Fakultni Nemocnice Hradec Kralove — Hradec Králové, Hradec Králové, Czechia (enrolling)
- Krajská nemocnice Liberec, a.s. — Liberec, Liberec, Czechia (enrolling)
- Institute For Clinical And Experimental Medicine — Prague, Prague, Czechia (enrolling)
- Klin Med s.r.o. — Prague, Prague, Czechia (enrolling)
- Hôpital Estaing — Clermont-Ferrand, France (enrolling)
- Hôpital Beaujon — Clichy, France (enrolling)
- University Hospital Henri Mondor - APHP — Créteil, France (enrolling)
- CHU Grenoble Alpes Hopital Nord Michallon — La Tronche, France (enrolling)
- Centre Hospitalier de Versailles _ Hopital Andre Magnot — Le Chesnay, France (enrolling)
- Lille Regional University Hospital Centre — Lille, France (enrolling)
- University Hospital Limoges — Limoges, France (enrolling)
- Hôpital de la Croix-Rousse — Lyon, France (enrolling)
- Hôpital Pitié Salpêtrière — Paris, France (enrolling)
- CHU de Bordeaux - Hopital Haut-Leveque — Pessac, France (enrolling)
- Centre Hospitalier Universitaire De Rennes — Rennes, France (enrolling)
- Hôpital Rangueil — Toulouse, France (enrolling)
- Goethe University Frankfurt — Frankfurt, Frankfurt, Germany (enrolling)
- Rostock University Medical Center — Rostock, Rostock, Germany (enrolling)
- Universitätsklinikum Düsseldorf — Düsseldorf, Germany (enrolling)
- Medizinische Hochschule Hannover — Hanover, Germany (enrolling)
- Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico — Milan, Italy (enrolling)
- AOU Pisana - Cisanello — Pisa, Italy (enrolling)
Full record on ClinicalTrials.gov
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