2-HOBA Supplementation in People With Elevated Lipoprotein(a)
Starting soon · Not applicable
Conditions studied: Hyperlipidemia, Elevated Lp(a)
In brief
The goal of this clinical trial is to learn if a natural supplement called 2-hydroxybenzylamine (2-HOBA) can reduce harmful oxidized lipids and improve the function of lipoprotein(a) in adults with high lipoprotein(a) levels. The main questions it aims to answer are: Does 2-HOBA lower oxidized phospholipids on lipoprotein(a)? Does 2-HOBA reduce markers of inflammation and blood clotting in the blood? Participants will: Take 2-HOBA capsules (400 mg, three times daily with meals) for 6 weeks Provide blood and urine samples at the beginning, middle, and end of the study Have lab tests to measure changes in lipids, inflammation, and clotting markers
Key facts
- Study ID
- NCT07198009
- Run by
- The Miriam Hospital
- People needed
- 10
- Starts
- 2025-11-01
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2025-09-30
Who can join
Age: 18 and older, up to 69. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Males and females aged 18-69 years.
- Elevated Lp(a) levels ≥ 90 mg/dL.
- Able to provide informed consent and adhere to study schedules.
- Willing to follow a physician-recommended diet during the study.
You may not qualify if…
- Pregnant, planning pregnancy during the study period, or currently breastfeeding.
- Individuals with established cardiovascular disease
- Planning major changes in diet or exercise routines.
- Experienced >20% weight change in the past 3 months.
- Diagnosed with malabsorption syndrome or chronic diarrhea.
- Abnormal liver, kidney, or thyroid function.
- Drug or alcohol abuse within the past 6 months, or significant mental/psychological impairment.
- Have known bleeding disorders (e.g., hemophilia).
- Planned surgery during the study period.
- Donated blood within the last 2 weeks or planning to donate during the study.
- Require regular blood transfusions.
Where it is running
- Lipid Clinic at Brown University Health — Providence, Rhode Island, United States
Full record on ClinicalTrials.gov
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