Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery

Starting soon · Not applicable

Conditions studied: Breast Cancer, Pain, Chronic, Post Surgical Pain

In brief

The goal of this clinical trial is to is to compare the effectiveness of ultrasound-guided Pecs block with intravenous ketamine versus intravenous ketamine infusion alone in preventing Chronic Post-Surgical Pain (CPSP) in patients undergoing breast cancer surgery. The main question it aims to answer is, How effective is the ketamine and ketamine with pecs block in reducing the frequency of Chronic Post-Surgical Pain after breast cancer surgery

Key facts

Study ID: NCT07197684
Run by: Aga Khan University
People needed: 120
Starts: 2026-03-16
Expected to finish: 2027-05-01
Last updated by the study team: 2026-02-19

Who can join

Age: 18 and older, up to 75. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Adult female patients with breast cancer aged between 18-75 years
ASA (American Society of Anesthesia) physical status I, II, and III
Patients scheduled for elective breast cancer surgery (Mastectomy with or without axillary clearance)

You may not qualify if…

Refusal to participate or withdrawal of informed consent
Surgical procedures involving breast reconstruction with flaps or implants
Patient scheduled for bilateral mastectomy
Reoperation on the same side due to cancer recurrence
Known allergy or contraindication to study drugs
History of severe psychiatric illness (e.g., major depression, bipolar disorder, schizophrenia)
Chronic opioid use, substance abuse, or opioid addiction
Pre-existing chronic pain or neuropathic pain disorders
Coagulopathy, anticoagulation therapy, or localized infection at the site of block
Uncontrolled hypertension and ischemic heart disease

Full record on ClinicalTrials.gov

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