Regenerative Potentials of Mature Mandibular Molars With Symptomatic Irreversible Pulpitis Enhanced With Different Scaffolds

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Conditions studied: Symptomatic Irreversible Pulpitis (SIP)

In brief

The current study aims to assess the influence of different scaffolds on postoperative pain and success rate of pulpotomy in mandibular mature molars with symptomatic irreversible pulpitis

Key facts

Study ID

NCT07196683

Run by

Cairo University

People needed

36

Starts

2026-07-01

Expected to finish

2027-11-01

Last updated by the study team

2026-03-27

Who can join

Age: 15 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ASA I patients who are free from any physical or mental handicapping condition with no underlying systemic disease.
• Age between 15-40 years.
• Males \& Females.
• Patients' acceptance to participate in the trial.
• Patients who can understand pain scale and can sign the informed consent (Appendix I).
• Mature mandibular fist molars:
• Diagnosed clinically with symptomatic irreversible pulpitis and normal periapical tissue.
• Giving a positive response to pulp sensitivity testing.
• Having negative response to percussion.
• Having normal radiographic appearance of periapical tissues.
• Having bright red color of pulp tissue, with hemorrhage control within 10 mins, upon access cavity preparation.

You may not qualify if…

• Pregnant and lactating females.
• Patients with physical or mental handicapping conditions.
• Patients unwilling to participate in a 12-months follow up.
• Mandibular first molars with:
• Immature roots.
• Negative response to pulp sensitivity testing.
• Positive response to percussion.
• Radiographic evidence of periapical lesions, external or internal root resorption, vertical root fracture, or calcification.
• Intraoral swelling or fistula.
• Lack of pulpal bleeding, or inability to achieve hemostasis of the bleeding pulp within 10 mins, upon access cavity preparation.

Where it is running

• Faculty of Dentistry, Cairo University — Cairo, Egypt

Full record on ClinicalTrials.gov

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