Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire

Recruiting now · Not applicable

Conditions studied: Endometrial Cancer, Lynch Syndrome

In brief

The goal of this study is to find out if self-collected vaginal swabs can be used to detect early signs of uterine cancer or related conditions in people with Lynch syndrome (LS) who still have their uterus. The study also tests if people with LS are willing and able to collect these samples themselves and whether they find the process acceptable. The main questions this study asks are: * Will people with LS take part in self-collection of vaginal samples, and do they find it acceptable? * Can vaginal DNA mutations predict cancer risk or match results from other genetic or biopsy testing? * Can a cancer risk model used in the general population also help identify risk in people with LS? Participants will: * Answer a health questionnaire about lifestyle and symptoms * Collect their own vaginal swabs and measure their vaginal pH at home using a self-collection kit * Complete short surveys around the time of self-collection and at the end of the study

Key facts

Study ID: NCT07194551
Run by: University of British Columbia
People needed: 30
Starts: 2025-08-29
Expected to finish: 2027-04-01
Last updated by the study team: 2025-09-26

Who can join

Age: 30 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Diagnosed with Lynch syndrome (confirmed by genetic testing).
Have an intact uterus.
Age 30 years or older.

You may not qualify if…

History of endometrial cancer or endometrial hyperplasia.
History of pelvic radiation or endometrial ablation.
Pregnant at the time of study enrolment or during the study.

Where it is running

VGH Research Pavilion — Vancouver, British Columbia, Canada (enrolling)

Full record on ClinicalTrials.gov

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