Altitude and Outcomes in Pediatric ARDS: A Multicenter Study

Recruiting now

Conditions studied: Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia, High Altitude Effects

In brief

This multicenter observational study will evaluate the association between geographic altitude, availability of critical care resources, and clinical outcomes in children with pediatric acute respiratory distress syndrome (PARDS). Data on demographics, physiology, and hospital structure will be collected from PICUs located at different altitudes worldwide. The study aims to identify gaps in PARDS management and provide recommendations adapted to diverse resource settings.

Key facts

Study ID

NCT07193771

Run by

Latin American Pediatric Collaborative Network

People needed

1600

Starts

2025-11-01

Expected to finish

2028-03-01

Last updated by the study team

2026-06-02

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 1 month (corrected gestational age) and 18 years.
• Admission to a pediatric intensive care unit (PICU) or facility where mechanically ventilated children are cared for.
• Requirement of invasive mechanical ventilation.
• Diagnosis of pediatric acute respiratory distress syndrome (PARDS) according to PALICC criteria, confirmed within 24 hours before or after endotracheal intubation.

You may not qualify if…

• Patients with active perinatal lung disease (e.g., neonatal respiratory distress syndrome, pulmonary hemorrhage, persistent pulmonary hypertension of the newborn, early bronchopulmonary dysplasia, meconium aspiration).
• Patients who have received extracorporeal membrane oxygenation (ECMO) prior to or within the first 24 hours of PARDS diagnosis.
• Patients with pre-established limitation of therapeutic effort (LTE) orders or palliative care directives documented before the initiation of invasive mechanical ventilation.
• Readmissions to the PICU during the study period (only the first episode per patient will be included).

Where it is running

• Círculo Católico — Montevideo, Uruguay (enrolling)
• Hospital del Norte - El Alto — La Paz, La Paz Department, Bolivia (enrolling)
• Hospital Daniel Brancamonte — Potosí, Potosí Department, Bolivia (enrolling)
• Hospital Regional San Juan de Dios — Tarija, Tarija Department, Bolivia (enrolling)
• Clinica Indisa — Santiago, Chile (enrolling)
• Hospital Universitario Clinica San Rafael — Bogotá, DC, Colombia (enrolling)
• Sociedad de Cirugia de Bogota Hospital de San Jose — Bogotá, DC, Colombia (enrolling)
• Fundación HOMI — Bogotá, DC, Colombia (enrolling)
• Hospital Militar Central de Bogotá — Bogotá, DC, Colombia (enrolling)
• Hospital Santa Clara — Bogotá, DC, Colombia (enrolling)
• Hospital Universitario San Ignacio — Bogotá, DC, Colombia (enrolling)
• Los Cobos Medical Center — Bogotá, DC, Colombia (enrolling)
• Fundacion Hospital Infantil Los Angeles — Pasto, Departamento de Nariño, Colombia (enrolling)
• Clínica UROS S.A — Neiva, Huila Department, Colombia (enrolling)
• Centro Hospitalario Pereira Rossell — Montevideo, Montevideo Department, Uruguay (enrolling)
• Hospital del Niño Sor Teresa Huarte Tama — Sucre, Chuquisaca Department, Bolivia (enrolling)
• Hospital de Emergencias Pediatricas — Lima, Lima Province, Peru (enrolling)
• Hospital Nacional Adolfo Guevara Velasco — Cusco, Peru (enrolling)
• Fundación Valle de Lili — Cali, Valle del Cauca Department, Colombia
• LaCardio — Bogotá, Colombia

Full record on ClinicalTrials.gov

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