NOPE37: Angiogenic Factors for Managing Term Preeclampsia
Recruiting now · Not applicable
Conditions studied: Preeclampsia
In brief
This study tests the hypothesis that, in women with preeclampsia without severe features, delivery management based on sFlt-1/PlGF would reduce the rate of induction of labor without worsening the rate of progression to preeclampsia with severe features and other maternal complications.
Key facts
- Study ID
- NCT07193680
- Run by
- Hospital Universitari Vall d'Hebron Research Institute
- People needed
- 750
- Starts
- 2025-12-04
- Expected to finish
- 2028-04-01
- Last updated by the study team
- 2025-12-11
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Singleton pregnancy
- Preeclampsia without severe features according to the ACOG definition
- Antegrade diastolic flow in the umbilical artery Doppler
- Gestational age between 36+0 and 38+6 weeks of gestation
- Gestational age confirmed by fetal crown-rump length measurement in the first-trimester scan (from 11+0 to 13+6 weeks of gestation) or by in vitro fertilization dates
You may not qualify if…
- Fetal death
- Preeclampsia with severe features according to the ACOG definition, eclampsia, or any condition that requires immediate delivery
- Absent or reversed end-diastolic flow in the umbilical artery Doppler
- Non-reassuring CTG
- Decreased fetal movements
- Biophysical profile score ≤6
- Oligohydramnios
- Refusal to provide informed consent
- Fetal malformation
- Placental abruption
- Antiphospholipid antibody syndrome
Where it is running
- Hospital Universitario de Torrejón — Torrejón, Spain (enrolling)
- Hospital Universitario Lozano Blesa — Zaragoza, Spain (enrolling)
- Hospital Universitari MútuaTerrassa — Terrassa, Spain (enrolling)
- Hospital Universitari Dexeus — Barcelona, BARCELONA, Spain (enrolling)
- Hospital Universitario de A Coruña — A Coruña, Spain (enrolling)
- Hospital General Universitari Dr. Balmis — Alicante, Spain (enrolling)
- Vall d'Hebron Hospital Campus — Barcelona, Spain (enrolling)
- Hospital Universitario de Cabueñes — Cabueñes, Spain (enrolling)
- Hospital Universitario Puerta del Mar — Cadiz, Spain (enrolling)
- Hospital General Universitario de Elche — Elche, Spain (enrolling)
- Hospital Universitario de Getafe — Getafe, Spain (enrolling)
- Hospital Universitari de Girona Doctor Josep Trueta — Girona, Spain (enrolling)
- Hospital Universitario San Cecilio — Granada, Spain (enrolling)
- Hospital Universitario de Jerez — Jerez de la Frontera, Spain (enrolling)
- Hospital Materno Infantil de Gran Canaria — Las Palmas de Gran Canaria, Spain (enrolling)
- Hospital Universitari Arnau de Vilanova — Lleida, Spain (enrolling)
- Hospital universitario 12 de Octubre — Madrid, Spain (enrolling)
- Hospital Clínico Universitario Virgen de la Arrixaca — Murcia, Spain (enrolling)
- Hospital Universitari Son Espases — Palma de Mallorca, Spain (enrolling)
- Hospital Universitario Virgen de Valme — Seville, Spain (enrolling)
- Hospital Universitario Virgen Macarena — Seville, Spain (enrolling)
- Hospital Universitari de Tarragona Joan XXIII — Tarragona, Spain (enrolling)
- Consorci Sanitari de Terrassa — Terrassa, Spain (enrolling)
Full record on ClinicalTrials.gov
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