Impact of Chronic and Acute Caffeine Intake on the Hematopoietic System

Recruiting now · Not applicable

Conditions studied: Healthy Adults; Hematopoietic System; Caffeine

In brief

This study investigates how caffeine intake affects blood stem and progenitor cells in healthy adults. The trial will compare people who regularly consume caffeine with those who consume very little or none. All participants will receive a single 200 mg caffeine tablet (similar to one cup of coffee) under fasting conditions. Blood samples will be collected before and three hours after caffeine intake. The study will assess whether caffeine influences the mobilization of blood stem and progenitor cells from the bone marrow into the bloodstream. It will also examine the effects of caffeine on the function, gene activity, and metabolism of blood cells.

Key facts

Study ID

NCT07193264

Run by

Jasmin Rettkowski

People needed

100

Starts

2025-11-05

Expected to finish

2028-06-01

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to give consent.
• Healthy adults aged ≥ 18 years.
• Regular caffeine consumers (≥1 coffee cup/day or ≥1 energy drink/day) or non-consumers (≤1 cup/month and ≤1 energy drink/month) for at least 6 months.
• Willingness to comply with fasting requirements and study procedures.

You may not qualify if…

• Chronic illnesses or medication use affecting metabolism, including metabolic disorders (e.g., diabetes, thyroid dysfunction, metabolic syndrome).
• Personal history of cancer.
• Personal history of hematological disorders.
• History of radiation therapy.
• Known caffeine hypersensitivity or intolerance.
• Known immunosuppression.

Where it is running

• ETH GLC — Zurich, Canton of Zurich, Switzerland (enrolling)
• ETH GLC — Zurich, Canton of Zurich, Switzerland

Full record on ClinicalTrials.gov

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